Hackney Police were called to Southwold Road, this evening shortly before 10pm on to reports of a shooting.
Officers attended the scene and found a 36-year-old male suffering from a gunshot wound to the leg.
He was taken by London Ambulance Service to an east London hospital where he remains in a serious condition.
A crime scene has been established and Southwold Road is subject to road closures.
No arrests have been made and enquiries continue.
Anyone who witnessed or has information concerning this incident should contact police by dialling 101 and quoting CAD9256/11.